Spiral microchannels on a CD for DNA hybridizations

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

42 Scopus Citations
View graph of relations

Author(s)

  • Xing Yue (Larry) Peng
  • Paul C.H. Li
  • Hua-Zhong Yu
  • M. Parameswaran (Ash)
  • Wa Lok (Jacky) Chou

Detail(s)

Original languageEnglish
Pages (from-to)64-69
Journal / PublicationSensors and Actuators, B: Chemical
Volume128
Issue number1
Publication statusPublished - 12 Dec 2007
Externally publishedYes

Abstract

Microfluidic devices on CD have benefited from the advantages of centrifugal pumping. To date, only channels in the radial direction have been used in these devices. In this work, we have designed numerous spiral channels on CD. Through a two-step assembly process, these spiral channels intersect with pre-immobilized radial DNA probe line to form an array of DNA that covers the whole CD surface. In our experiments, 96 radial channels were used for the first step of DNA probe immobilizations. Then, 96 spiral channels were used for the second step of hydrodynamic DNA sample hybridizations. The 96 × 96 intersections between the spiral channels and radial lines of DNA probes created a multi-sample-multi-probe array on a CD. © 2007.

Research Area(s)

  • Centrifugal pumping, DNA microarray, Dynamic DNA hybridization, Microfluidic devices, Spiral channel

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Spiral microchannels on a CD for DNA hybridizations. / Peng, Xing Yue (Larry); Li, Paul C.H.; Yu, Hua-Zhong; (Ash), M. Parameswaran; Chou, Wa Lok (Jacky).

In: Sensors and Actuators, B: Chemical, Vol. 128, No. 1, 12.12.2007, p. 64-69.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review