Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

Hengxin Feng; Chun Kit Kwok

doi:10.1039/d2cb00045h

Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

Hengxin Feng, Chun Kit Kwok^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

44 Downloads (CityUHK Scholars)

Abstract

We study and uncover the effect of hairpin structures in loops of G-quadruplexes using spectroscopic methods. Notably, we show that the sequence, structure, and position of the hairpin loop control the spectroscopic properties of long loop G-quadruplexes, and highlight that intrinsic fluorescence can be used to monitor the formation of non-canonical G-quadruplexes.

Original language	English
Pages (from-to)	431-435
Journal	RSC Chemical Biology
Volume	3
Issue number	4
Online published	10 Mar 2022
DOIs	https://doi.org/10.1039/d2cb00045h
Publication status	Published - 1 Apr 2022

Funding

We acknowledge Danyang Ji for discussion and funding from Shenzhen Basic Research Project [JCYJ20180507181642811]; Research Grants Council of the HKSAR, China Projects [CityU 11100421, CityU 11101519, CityU 11100218, N_CityU110/17]; Croucher Foundation Project [9509003]; State Key Laboratory of Marine Pollution Director Discretionary Fund; and City University of Hong Kong Projects [7005503, 9667222, 9680261] to C. K. K.

Research Keywords

INTRINSIC FLUORESCENCE
SEQUENCE

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This full text is made available under CC-BY 3.0. https://creativecommons.org/licenses/by/3.0/

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KW - SEQUENCE

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Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures

Abstract

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Research Keywords

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