Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

4 Scopus Citations
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Original languageEnglish
Pages (from-to)2616-2619
Journal / PublicationChemical Communications
Volume55
Issue number18
Online published29 Jan 2019
Publication statusPublished - 4 Mar 2019

Abstract

Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.