Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

Chun-Yin Chan; Mubarak I. Umar; Chun Kit Kwok

doi:10.1039/c8cc09929d

Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

Chun-Yin Chan, Mubarak I. Umar, Chun Kit Kwok^*

^*Corresponding author for this work

Department of Chemistry

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

20 Citations (Scopus)

Abstract

Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.

Original language	English
Pages (from-to)	2616-2619
Journal	Chemical Communications
Volume	55
Issue number	18
Online published	29 Jan 2019
DOIs	https://doi.org/10.1039/c8cc09929d
Publication status	Published - 4 Mar 2019

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title = "Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures",

abstract = "Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.",

author = "Chun-Yin Chan and Umar, {Mubarak I.} and Kwok, {Chun Kit}",

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AU - Umar, Mubarak I.

AU - Kwok, Chun Kit

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.

AB - Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.

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U2 - 10.1039/c8cc09929d

DO - 10.1039/c8cc09929d

M3 - RGC 21 - Publication in refereed journal

C2 - 30724299

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VL - 55

SP - 2616

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

Abstract

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