TY - JOUR
T1 - Spectral analysis of microarray gene expression time series data of Plasmodium falciparum
AU - Du, Liping
AU - Wu, Shuanhu
AU - Liew, Alan Wee-Chung
AU - Smith, David K.
AU - Yan, Hong
PY - 2008/7
Y1 - 2008/7
N2 - We propose a new strategy to analyse the periodicity of gene expression profiles using Singular Spectrum Analysis (SSA) and Autoregressive (AR) model based spectral estimation. By combining the advantages of SSA and AR modelling, more periodic genes are extracted in the Plasmodium falciparum data set, compared with the classical Fourier analysis technique. We are able to identify more gene targets for new drug discovery, and by checking against the seven well-known malaria vaccine candidates, we have found five additional genes that warrant further biological verification. Copyright © 2008 Inderscience Enterprises Ltd.
AB - We propose a new strategy to analyse the periodicity of gene expression profiles using Singular Spectrum Analysis (SSA) and Autoregressive (AR) model based spectral estimation. By combining the advantages of SSA and AR modelling, more periodic genes are extracted in the Plasmodium falciparum data set, compared with the classical Fourier analysis technique. We are able to identify more gene targets for new drug discovery, and by checking against the seven well-known malaria vaccine candidates, we have found five additional genes that warrant further biological verification. Copyright © 2008 Inderscience Enterprises Ltd.
KW - AR
KW - Autoregressive
KW - Bioinformatics
KW - Gene target
KW - Microarray time series analysis
KW - Model
KW - Plasmodium falciparum
KW - Singular spectrum analysis
KW - SSA
UR - http://www.scopus.com/inward/record.url?scp=47749135602&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-47749135602&origin=recordpage
U2 - 10.1504/IJBRA.2008.019579
DO - 10.1504/IJBRA.2008.019579
M3 - RGC 21 - Publication in refereed journal
C2 - 18640908
SN - 1744-5458
VL - 4
SP - 337
EP - 349
JO - International Journal of Bioinformatics Research and Applications
JF - International Journal of Bioinformatics Research and Applications
IS - 3
ER -
