Specific Binding of a D-RNA G-Quadruplex Structure with an L-RNA Aptamer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)5293-5297
Journal / PublicationAngewandte Chemie - International Edition
Issue number13
Online published23 Jan 2020
Publication statusPublished - 23 Mar 2020


G-quadruplex (G4) structures are of general importance in chemistry and biology, such as in biosensing, gene regulation, and cancers. Although a large repertoire of G4-binding tools has been developed, no aptamer has been developed to interact with G4. Moreover, the G4 selectivity of current toolkits is very limited. Herein, we report the first L-RNA aptamer that targets a D-RNA G-quadruplex (rG4). Using TERRA rG4 as an example, our results reveal that this l-RNA aptamer, Ap3-7, folds into a unique secondary structure, exhibits high G4 selectivity and effectively interferes with TERRA-rG4–RHAU53 binding. Our approach and findings open a new door in further developing G4-specific tools for diverse applications.

Research Area(s)

  • aptamers, G-quadruplexes, nucleic acids, RNA, RNA structures

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