TY - GEN
T1 - Spatial Interactions of Electrically Evoked Potentials in Visual Cortex Induced by Multi-retinal Electrical Stimulation in Rats
AU - Xie, Hui
AU - Wang, Yi
AU - Chan, Leanne Lai-Hang
PY - 2019
Y1 - 2019
N2 - Retinal prostheses are designed to electrically stimulate retinal neurons to generate artificial vision in patients with degenerative diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Considering hundreds of microelectrodes may be applied in the future retinal prosthesis to provide enough spatial information for precise perception, it is crucial to investigate the spatial properties of the visual cortex in response to retinal electric stimulation via in vivo studies, especially in multi-stimulating manner by adjacent electrodes. In this study, we use retinal multi-stimulating electrodes to stimulate retinal ganglion cells (RGCs) and record electrically evoked potentials (EEPs) in contralateral visual cortex by a 32-channel Utah array. The threshold of eliciting current for EEPs was determined with 20% of the maximum response in visual cortex. The spatial map with 32 grids for single retinal stimulation was obtained firstly, which showed the different spatial distribution to different retinal stimulation. Then the combination of two stimulation from two adjacent retinal stimulating electrode was applied to examine the spatial responses of visual cortex.
AB - Retinal prostheses are designed to electrically stimulate retinal neurons to generate artificial vision in patients with degenerative diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Considering hundreds of microelectrodes may be applied in the future retinal prosthesis to provide enough spatial information for precise perception, it is crucial to investigate the spatial properties of the visual cortex in response to retinal electric stimulation via in vivo studies, especially in multi-stimulating manner by adjacent electrodes. In this study, we use retinal multi-stimulating electrodes to stimulate retinal ganglion cells (RGCs) and record electrically evoked potentials (EEPs) in contralateral visual cortex by a 32-channel Utah array. The threshold of eliciting current for EEPs was determined with 20% of the maximum response in visual cortex. The spatial map with 32 grids for single retinal stimulation was obtained firstly, which showed the different spatial distribution to different retinal stimulation. Then the combination of two stimulation from two adjacent retinal stimulating electrode was applied to examine the spatial responses of visual cortex.
UR - http://www.scopus.com/inward/record.url?scp=85059737699&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85059737699&origin=recordpage
U2 - 10.1007/978-981-10-4505-9_20
DO - 10.1007/978-981-10-4505-9_20
M3 - RGC 32 - Refereed conference paper (with host publication)
SN - 9789811045042
T3 - IFMBE Proceedings
SP - 123
EP - 128
BT - International Conference on Biomedical and Health Informatics - ICBHI 2015
A2 - Zhang, Yuan-Ting
A2 - Carvalho, Paulo
A2 - Magjarevic, Ratko
PB - Springer Nature Singapore Pte Ltd.
T2 - International Conference on Biomedical and Health Informatics (ICBHI 2015)
Y2 - 8 October 2015 through 10 October 2015
ER -