TY - JOUR
T1 - Solar-Driven Overproduction of Biofuels in Microorganisms
AU - Wang, Jie
AU - Chen, Na
AU - Bian, Guangkai
AU - Mu, Xin
AU - Du, Na
AU - Wang, Wenjie
AU - Ma, Chong-Geng
AU - Fu, Shai
AU - Huang, Bolong
AU - Liu, Tiangang
AU - Yang, Yanbing
AU - Yuan, Quan
PY - 2022/8/8
Y1 - 2022/8/8
N2 - Microbial cell factories reinvigorate current industries by producing complex fine chemicals at low costs. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the main reducing power to drive the biosynthetic pathways in microorganisms. However, insufficient intrinsic NADPH limits the productivity of microorganisms. Here, we report that supplying microorganisms with long-lived electrons from persistent phosphor mesoporous Al2O3 (meso-Al2O3) can elevate the NADPH level to facilitate efficient fine chemical production. The defects in meso-Al2O3 were demonstrated to be highly efficient in prolonging electrons’ lifetime. The long-lived electrons in meso-Al2O3 can pass the material–microorganism interface and power the biosynthetic pathways of E. coli to produce jet fuel farnesene. This work represents a reliable strategy to design photo-biosynthesis systems to improve the productivity of microorganisms with solar energy. © 2022 Wiley-VCH GmbH.
AB - Microbial cell factories reinvigorate current industries by producing complex fine chemicals at low costs. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the main reducing power to drive the biosynthetic pathways in microorganisms. However, insufficient intrinsic NADPH limits the productivity of microorganisms. Here, we report that supplying microorganisms with long-lived electrons from persistent phosphor mesoporous Al2O3 (meso-Al2O3) can elevate the NADPH level to facilitate efficient fine chemical production. The defects in meso-Al2O3 were demonstrated to be highly efficient in prolonging electrons’ lifetime. The long-lived electrons in meso-Al2O3 can pass the material–microorganism interface and power the biosynthetic pathways of E. coli to produce jet fuel farnesene. This work represents a reliable strategy to design photo-biosynthesis systems to improve the productivity of microorganisms with solar energy. © 2022 Wiley-VCH GmbH.
KW - Bacteria
KW - Defects
KW - Mesoporous Materials
KW - Persistent Luminescence
KW - Photosynthesis
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85132548243&origin=recordpage
U2 - 10.1002/anie.202207132
DO - 10.1002/anie.202207132
M3 - RGC 21 - Publication in refereed journal
C2 - 35653160
SN - 1433-7851
VL - 61
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 32
M1 - e202207132
ER -
