Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yang Li
  • Lei Li
  • Liren Zhu
  • Konstantin Maslov
  • Junhui Shi
  • Peng Hu
  • En Bo
  • Junjie Yao
  • Jinyang Liang
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Pages (from-to)164–170
Journal / PublicationNature Photonics
Volume14
Issue number3
Online published20 Jan 2020
Publication statusPublished - Mar 2020
Externally publishedYes

Abstract

Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic topography through an ergodic relay (PATER) for low-cost high-throughput snapshot wide-field imaging. Encoding spatial information with randomized temporal signatures through ergodicity, PATER requires only a single-element ultrasonic transducer to capture a wide-field image with a single laser shot. We applied PATER to demonstrate both functional imaging of haemodynamic responses and high-speed imaging of blood pulse wave propagation in mice in vivo. Leveraging the high frame rate of 2 kHz, PATER tracked and localized moving melanoma tumour cells in the mouse brain in vivo, which enabled flow velocity quantification and super-resolution imaging. Among the potential biomedical applications of PATER, wearable devices to monitor human vital signs in particular is envisaged.

Citation Format(s)

Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption. / Li, Yang; Li, Lei; Zhu, Liren et al.
In: Nature Photonics, Vol. 14, No. 3, 03.2020, p. 164–170.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review