Smart Vascular Grafts with Integrated Flow Biosensors for Hemodynamic Real-Time Monitoring and Vascular Healthcare

Real-time monitoring of hemodynamics is crucial for diagnosing disorders within implanted vascular grafts and facilitating timely treatment. Integrating vascular grafts with advanced flexible electronics offers a promising approach to developing smart vascular grafts (SVGs) capable of continuous hemodynamic monitoring. However, most existing SVG devices encounter significant challenges in practical applications, particularly regarding biomechanical compatibility and the effective evaluation of vascular status. Here, we present a state-of-the-art SVG device seamlessly integrated with flow biosensors constructed by encapsulating patterned porous graphene within biocompatible polymers. The innovative use of porous graphene imparts the SVG with exceptional mechanical sensing performance, featuring a low strain detection limit of 0.0034% and dynamic stability exceeding 32,400 cycles, thus enabling precise hemodynamic perception. This high sensitivity allows the SVG to accurately diagnose vascular disorders, such as blockage degree and position, by collecting hemodynamic data from an artificial artery model. In vitro thrombi (blood clot) diagnostics, treatment simulation experiments, and in vivo tests using a rabbit model strongly validate the SVG’s outstanding and reliable performance in vascular healthcare. We have also developed a stand-alone and wireless system, demonstrating its capability for remote monitoring and managing vascular health. Our pioneering SVG system showcases great potential in vascular healthcare for precise hemodynamic monitoring of disorders, timely diagnostics, and even drug screening. © 2025 American Chemical Society.