Small Upconverting Fluorescent Nanoparticles for Biosensing and Bioimaging

Guang-Rong Tan; Menghan Wang; Chin-Ying Hsu; Nanguang Chen; Yong Zhang

doi:10.1002/adom.201600141

Small Upconverting Fluorescent Nanoparticles for Biosensing and Bioimaging

Guang-Rong Tan
, Menghan Wang
, Chin-Ying Hsu
, Nanguang Chen
, Yong Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

114 Citations (Scopus)

Abstract

Rapid progress in biological sensing and imaging technologies offers new and exciting opportunities to identify biochemical changes fundamental to preclinical research that may develop into the next generation of point-of-care devices. Small upconverting fluorescent nanoparticles (UCNPs) are a special class of lanthanide-doped, optically active, microscopic particles that fluoresce upon near-infrared light activation. With the additional advantages of deep penetration, minimal photodamage, and low background fluorescence in biological tissues, biosensors incorporating these lanthanide nanoparticles are rapidly emerging as serious contenders to rival the traditional downconversion-based fluorescence nanoparticles. Emphasizing on two application areas, namely biosensing and bioimaging, the recent developments in lanthanide-based UCNP design for optimum upconversion efficiency are reviewed. The article discusses the use of UCNPs in biosensing and bioimaging, highlights the challenges that hamper further applications, and concludes with future directions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English
Pages (from-to)	984-997
Journal	Advanced Optical Materials
Volume	4
Issue number	7
DOIs	https://doi.org/10.1002/adom.201600141
Publication status	Published - 1 Jul 2016
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was supported by the National University of Singapore.

Research Keywords

bioimaging
biosensing
upconversion nanoparticles

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abstract = "Rapid progress in biological sensing and imaging technologies offers new and exciting opportunities to identify biochemical changes fundamental to preclinical research that may develop into the next generation of point-of-care devices. Small upconverting fluorescent nanoparticles (UCNPs) are a special class of lanthanide-doped, optically active, microscopic particles that fluoresce upon near-infrared light activation. With the additional advantages of deep penetration, minimal photodamage, and low background fluorescence in biological tissues, biosensors incorporating these lanthanide nanoparticles are rapidly emerging as serious contenders to rival the traditional downconversion-based fluorescence nanoparticles. Emphasizing on two application areas, namely biosensing and bioimaging, the recent developments in lanthanide-based UCNP design for optimum upconversion efficiency are reviewed. The article discusses the use of UCNPs in biosensing and bioimaging, highlights the challenges that hamper further applications, and concludes with future directions. {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

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AU - Tan, Guang-Rong

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AU - Hsu, Chin-Ying

AU - Chen, Nanguang

AU - Zhang, Yong

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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N2 - Rapid progress in biological sensing and imaging technologies offers new and exciting opportunities to identify biochemical changes fundamental to preclinical research that may develop into the next generation of point-of-care devices. Small upconverting fluorescent nanoparticles (UCNPs) are a special class of lanthanide-doped, optically active, microscopic particles that fluoresce upon near-infrared light activation. With the additional advantages of deep penetration, minimal photodamage, and low background fluorescence in biological tissues, biosensors incorporating these lanthanide nanoparticles are rapidly emerging as serious contenders to rival the traditional downconversion-based fluorescence nanoparticles. Emphasizing on two application areas, namely biosensing and bioimaging, the recent developments in lanthanide-based UCNP design for optimum upconversion efficiency are reviewed. The article discusses the use of UCNPs in biosensing and bioimaging, highlights the challenges that hamper further applications, and concludes with future directions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - Rapid progress in biological sensing and imaging technologies offers new and exciting opportunities to identify biochemical changes fundamental to preclinical research that may develop into the next generation of point-of-care devices. Small upconverting fluorescent nanoparticles (UCNPs) are a special class of lanthanide-doped, optically active, microscopic particles that fluoresce upon near-infrared light activation. With the additional advantages of deep penetration, minimal photodamage, and low background fluorescence in biological tissues, biosensors incorporating these lanthanide nanoparticles are rapidly emerging as serious contenders to rival the traditional downconversion-based fluorescence nanoparticles. Emphasizing on two application areas, namely biosensing and bioimaging, the recent developments in lanthanide-based UCNP design for optimum upconversion efficiency are reviewed. The article discusses the use of UCNPs in biosensing and bioimaging, highlights the challenges that hamper further applications, and concludes with future directions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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KW - upconversion nanoparticles

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JO - Advanced Optical Materials

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Small Upconverting Fluorescent Nanoparticles for Biosensing and Bioimaging

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