Slow Release from a Coated Sphere with Slight Deformations of Coating Film and Drug Matrix

Y. C. Liao; D. J. Lee

doi:10.1021/js960143c

Slow Release from a Coated Sphere with Slight Deformations of Coating Film and Drug Matrix

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Overview

20 Scopus Citations

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Author(s)

Y. C. Liao
D. J. Lee

Detail(s)

Original language	English
Pages (from-to)	92-100
Journal / Publication	Journal of Pharmaceutical Sciences
Volume	86
Issue number	1
Publication status	Published - 1997
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1021/js960143c Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-0030640970&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(854ceac8-3505-4264-aba7-1f39fdb6e992).html

Abstract

This paper, a continuation of our previous work, is a presentation of the effects of slight deformations of both the coating film and the drug matrix on the concentration distributions and the slow release characteristics of a coated drug particle. The coated particle shape, in practice, is not perfectly spherical. With restriction of the deformation shape functions considered, it is noted that if the deformation is slight or if only the average release rate is of interest, the effects of shape deformation are secondary. Otherwise, the shape deformation can have a significant effect on the concentration profiles and/or the release rate from different parts of the particle surface. The deformations of both coating film and the drug matrix could introduce a greater deviation from the spherical case than those considering only coating film or drug matrix shape deformation.

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