TY - JOUR
T1 - Slow Release from a Coated Sphere with Slight Deformations of Coating Film and Drug Matrix
AU - Liao, Y. C.
AU - Lee, D. J.
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 1997
Y1 - 1997
N2 - This paper, a continuation of our previous work, is a presentation of the effects of slight deformations of both the coating film and the drug matrix on the concentration distributions and the slow release characteristics of a coated drug particle. The coated particle shape, in practice, is not perfectly spherical. With restriction of the deformation shape functions considered, it is noted that if the deformation is slight or if only the average release rate is of interest, the effects of shape deformation are secondary. Otherwise, the shape deformation can have a significant effect on the concentration profiles and/or the release rate from different parts of the particle surface. The deformations of both coating film and the drug matrix could introduce a greater deviation from the spherical case than those considering only coating film or drug matrix shape deformation.
AB - This paper, a continuation of our previous work, is a presentation of the effects of slight deformations of both the coating film and the drug matrix on the concentration distributions and the slow release characteristics of a coated drug particle. The coated particle shape, in practice, is not perfectly spherical. With restriction of the deformation shape functions considered, it is noted that if the deformation is slight or if only the average release rate is of interest, the effects of shape deformation are secondary. Otherwise, the shape deformation can have a significant effect on the concentration profiles and/or the release rate from different parts of the particle surface. The deformations of both coating film and the drug matrix could introduce a greater deviation from the spherical case than those considering only coating film or drug matrix shape deformation.
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U2 - 10.1021/js960143c
DO - 10.1021/js960143c
M3 - RGC 21 - Publication in refereed journal
C2 - 9002466
SN - 0022-3549
VL - 86
SP - 92
EP - 100
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 1
ER -