TY - JOUR
T1 - Slow release from a coated sphere with a slightly deformed coating
AU - Lee, D. J.
AU - Liao, Y. C.
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 1995/11
Y1 - 1995/11
N2 - Effects of a slight deformation of the coating film on the concentration distribution and the slow release characteristics of a coated drug particle is theoretically investigated in this work. A perturbation technique is employed for transformation of the deformed spherical problem into a series of concentric spherical problems with the degree of deformation considered as the perturbation parameter. In addition, the governing equations are solved analytically by further restricting the deformation shape function. Results in this study indicate that if the deformation is slight or only the average release rate is of interest, the effects of coating shape deformation are secondary. However, if the deformation is not so small and if the drug diffusivity in the film is low, the shape deformation could have a significant effect on the concentration profiles and/or the release rate from different parts of the particle surface. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company
AB - Effects of a slight deformation of the coating film on the concentration distribution and the slow release characteristics of a coated drug particle is theoretically investigated in this work. A perturbation technique is employed for transformation of the deformed spherical problem into a series of concentric spherical problems with the degree of deformation considered as the perturbation parameter. In addition, the governing equations are solved analytically by further restricting the deformation shape function. Results in this study indicate that if the deformation is slight or only the average release rate is of interest, the effects of coating shape deformation are secondary. However, if the deformation is not so small and if the drug diffusivity in the film is low, the shape deformation could have a significant effect on the concentration profiles and/or the release rate from different parts of the particle surface. Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company
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U2 - 10.1002/jps.2600841119
DO - 10.1002/jps.2600841119
M3 - RGC 21 - Publication in refereed journal
C2 - 8587057
SN - 0022-3549
VL - 84
SP - 1366
EP - 1373
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 11
ER -