Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

Li Yan; Xianfeng Chen; Zhigang Wang; Xiujuan Zhang; Xiaoyue Zhu; Mengjiao Zhou; Wei Chen; Longbiao Huang; Vellaisamy A. L. Roy; Peter K. N. Yu; Guangyu Zhu; Wenjun Zhang

doi:10.1021/acsami.7b10064

Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

Li Yan
, Xianfeng Chen^*
, Zhigang Wang
, Xiujuan Zhang
, Xiaoyue Zhu
, Mengjiao Zhou
, Wei Chen
, Longbiao Huang
, Vellaisamy A. L. Roy
, Peter K. N. Yu
, Guangyu Zhu
, Wenjun Zhang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

84 Citations (Scopus)

Abstract

Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8−poly(acrylic acid sodium salt) (ZIF-8−PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8−PAAS
nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal−organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.

Original language	English
Pages (from-to)	32990-33000
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	38
Online published	6 Sept 2017
DOIs	https://doi.org/10.1021/acsami.7b10064
Publication status	Published - 27 Sept 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

drug delivery
metal-organic frameworks
nanocomposites
nanomaterials
ZIF-8

RGC Funding Information

RGC-funded

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10.1021/acsami.7b10064

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Yan, L., Chen, X., Wang, Z., Zhang, X., Zhu, X., Zhou, M., Chen, W., Huang, L., Roy, V. A. L., Yu, P. K. N., Zhu, G., & Zhang, W. (2017). Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment. ACS Applied Materials and Interfaces, 9(38), 32990-33000. https://doi.org/10.1021/acsami.7b10064

@article{d22b831059d2401890f705437487404b,

title = "Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment",

abstract = "Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8−poly(acrylic acid sodium salt) (ZIF-8−PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8−PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal−organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.",

keywords = "drug delivery, metal-organic frameworks, nanocomposites, nanomaterials, ZIF-8",

author = "Li Yan and Xianfeng Chen and Zhigang Wang and Xiujuan Zhang and Xiaoyue Zhu and Mengjiao Zhou and Wei Chen and Longbiao Huang and Roy, \{Vellaisamy A. L.\} and Yu, \{Peter K. N.\} and Guangyu Zhu and Wenjun Zhang",

year = "2017",

month = sep,

day = "27",

doi = "10.1021/acsami.7b10064",

language = "English",

volume = "9",

pages = "32990--33000",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

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}

Yan, L, Chen, X, Wang, Z, Zhang, X, Zhu, X, Zhou, M, Chen, W, Huang, L, Roy, VAL , Yu, PKN , Zhu, G & Zhang, W 2017, 'Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment', ACS Applied Materials and Interfaces, vol. 9, no. 38, pp. 32990-33000. https://doi.org/10.1021/acsami.7b10064

Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment. / Yan, Li; Chen, Xianfeng; Wang, Zhigang et al.
In: ACS Applied Materials and Interfaces, Vol. 9, No. 38, 27.09.2017, p. 32990-33000.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

AU - Yan, Li

AU - Chen, Xianfeng

AU - Wang, Zhigang

AU - Zhang, Xiujuan

AU - Zhu, Xiaoyue

AU - Zhou, Mengjiao

AU - Chen, Wei

AU - Huang, Longbiao

AU - Roy, Vellaisamy A. L.

AU - Yu, Peter K. N.

AU - Zhu, Guangyu

AU - Zhang, Wenjun

PY - 2017/9/27

Y1 - 2017/9/27

N2 - Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8−poly(acrylic acid sodium salt) (ZIF-8−PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8−PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal−organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.

AB - Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8−poly(acrylic acid sodium salt) (ZIF-8−PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8−PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal−organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.

KW - drug delivery

KW - metal-organic frameworks

KW - nanocomposites

KW - nanomaterials

KW - ZIF-8

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U2 - 10.1021/acsami.7b10064

DO - 10.1021/acsami.7b10064

M3 - RGC 21 - Publication in refereed journal

SN - 1944-8244

VL - 9

SP - 32990

EP - 33000

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 38

ER -

Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

Abstract

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Research Keywords

RGC Funding Information

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GRF: Group-VI Element-Doped Carbon Nanoparticles for Phototherapeutic Applications

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Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8-Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment

Abstract

UN SDGs

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Group-VI Element-Doped Carbon Nanoparticles for Phototherapeutic Applications

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