Abstract
A study was conducted to demonstrate the size and concentration effect of gold nanoparticles (GNPs) on X-ray attenuation measured by computed tomography (CT). The GNPs were prepared by borohydride reduction of gold salts in the presence of sodium citrate. The X-ray attenuation of GNPs at different concentrations was compared with a commercial iodinated-contrast agent, Omnipaque. It was observed that on increasing the concentration of GNPs, gold dominates the X-ray attenuation due to the high X-ray attenuation effect of gold. It is investigated that the smaller GNPs showed greater X-ray attenuation than either the large ones. It is concluded that the MSA-coated GNPs with size ranging from 4 to 60 nm are stable in physiological conditions and are nontoxic to HeLa S3 cells. The X-ray attenuation from GNPs is both size and concentration dependent with smaller GNPs at higher concentration exhibiting greater effect.
| Original language | English |
|---|---|
| Pages (from-to) | 4167-4169 |
| Journal | Chemistry of Materials |
| Volume | 20 |
| Issue number | 13 |
| Online published | 4 Jun 2008 |
| DOIs | |
| Publication status | Published - 8 Jul 2008 |
| Externally published | Yes |
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