SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 11593-11606 |
Journal / Publication | ACS Nano |
Volume | 17 |
Issue number | 12 |
Online published | 12 Jun 2023 |
Publication status | Published - 27 Jun 2023 |
Externally published | Yes |
Link(s)
Abstract
Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy of irradiance and insufficient therapeutic depth. Here we report the design and preclinical validation of a flexible wireless upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable of large field, high intensity illumination for PDT of deep-seated tumors. The implant achieves this by incorporating submicrometer core-shell-shell NaYF4 UCNPs into its design, which significantly enhances upconversion efficiency and mitigates light loss from surface quenching. We demonstrate the efficacy of SIRIUS UCNP implant mediated PDT in preclinical breast cancer disease models. In our in vitro experiments, SIRIUS directed 5-Aminolevulinic Acid (5-ALA) based wireless PDT leads to significant reactive oxygen species (ROS) generation and tumor apoptosis in hormonal receptor+/HER2+ (MCF7) and triple-negative (MDA-MB-231) breast cancer cell lines. In our in vivo rodent model, SIRIUS-driven PDT is shown to be significant in regressing tumors when applied to orthotopically inoculated breast tumors. Following successful preclinical validation, we also describe a clinical prototype of UCNP breast implant with potential dual cosmetic and onco-therapeutic functions. SIRIUS is an upconversion breast implant for wireless PDT that fulfils all the design prerequisites necessary for seamless clinical translation. © 2023 American Chemical Society.
Research Area(s)
- 5-aminolevulinic acid, breast cancer, near-infrared, Photodynamic therapy, upconversion nanoparticle implant
Citation Format(s)
SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. / Kamarudin, Jannah Binte Mohamed; Sun, Bowen; Foo, Aaron Song Chuan et al.
In: ACS Nano, Vol. 17, No. 12, 27.06.2023, p. 11593-11606.
In: ACS Nano, Vol. 17, No. 12, 27.06.2023, p. 11593-11606.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review