SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Jannah Binte Mohamed Kamarudin
  • Bowen Sun
  • Aaron Song Chuan Foo
  • Xin-Yuan Lim
  • Heevah Judd
  • Xingfei Tan
  • Xuan Hao Tan
  • Rafhanah Banu Binte Abdul Razar
  • Min Liu
  • Jinglin Zhong
  • John Jia En Chua
  • Celene Wei Qi Ng
  • James C. H. Goh
  • Tuan Zea Tan
  • Bhav Harshad Parikh
  • Xinyi Su
  • Alan Prem Kumar
  • Wei Yi Ong
  • Naoki Yamaguchi
  • Sze Y. Set
  • George W. Yip
  • Daniel Boon Loong Teh

Detail(s)

Original languageEnglish
Pages (from-to)11593-11606
Journal / PublicationACS Nano
Volume17
Issue number12
Online published12 Jun 2023
Publication statusPublished - 27 Jun 2023
Externally publishedYes

Abstract

Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy of irradiance and insufficient therapeutic depth. Here we report the design and preclinical validation of a flexible wireless upconversion nanoparticle (UCNP) implant (SIRIUS) that is capable of large field, high intensity illumination for PDT of deep-seated tumors. The implant achieves this by incorporating submicrometer core-shell-shell NaYF4 UCNPs into its design, which significantly enhances upconversion efficiency and mitigates light loss from surface quenching. We demonstrate the efficacy of SIRIUS UCNP implant mediated PDT in preclinical breast cancer disease models. In our in vitro experiments, SIRIUS directed 5-Aminolevulinic Acid (5-ALA) based wireless PDT leads to significant reactive oxygen species (ROS) generation and tumor apoptosis in hormonal receptor+/HER2+ (MCF7) and triple-negative (MDA-MB-231) breast cancer cell lines. In our in vivo rodent model, SIRIUS-driven PDT is shown to be significant in regressing tumors when applied to orthotopically inoculated breast tumors. Following successful preclinical validation, we also describe a clinical prototype of UCNP breast implant with potential dual cosmetic and onco-therapeutic functions. SIRIUS is an upconversion breast implant for wireless PDT that fulfils all the design prerequisites necessary for seamless clinical translation. © 2023 American Chemical Society.

Research Area(s)

  • 5-aminolevulinic acid, breast cancer, near-infrared, Photodynamic therapy, upconversion nanoparticle implant

Citation Format(s)

SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. / Kamarudin, Jannah Binte Mohamed; Sun, Bowen; Foo, Aaron Song Chuan et al.
In: ACS Nano, Vol. 17, No. 12, 27.06.2023, p. 11593-11606.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review