Single-fibre EPSPs in layer 5 of rat visual cortex in vitro

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)167-170
Journal / PublicationNeuroReport
Volume4
Issue number2
Publication statusPublished - Feb 1993
Externally publishedYes

Abstract

SIMULTANEOUS intracellular recordings were made from pairs of sy naptically connected layer 5 pyramidal neurones less than 150 μm apart, in slices of rat visual cortex. Action potentials were evoked in one cell of a pair by depolarizing current pulses, while spike-triggered averaging was employed to reveal connections in the other cell and vice versa. Only 4 excitatory postsynaptic potentials (EPSPs) (0.7-1.2 mV) were recorded out of 270 cell pairs tested, equivalent to a connection probability of less than 0.02. Therefore, single-fibre EPSPs between pyramidal cells in layer 5 are less frequent, but individually larger in amplitude, than those found previously between pyramidal cells in layer 2/3 of rat visual cortex. © Rapid Communications of Oxford Ltd.

Research Area(s)

  • Connection probability, Intracellular recording, Pyramidal neurones, Single-fibre excitatory postsynaptic potential (EPSP), Visual cortex

Bibliographic Note

Publication information for this record has been verified with the author(s) concerned.

Citation Format(s)

Single-fibre EPSPs in layer 5 of rat visual cortex in vitro. / Nicoll, Andrew; Blakemore, Colin.
In: NeuroReport, Vol. 4, No. 2, 02.1993, p. 167-170.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review