Single-cell photoacoustic thermometry

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

66 Scopus Citations
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Author(s)

  • Liang Gao
  • Chiye Li
  • Yan Liu
  • Haixin Ke
  • Chi Zhang
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Article number26003
Journal / PublicationJournal of Biomedical Optics
Volume18
Issue number2
Publication statusPublished - Feb 2013
Externally publishedYes

Abstract

A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community. © Society of Photo-Optical Instrumentation Engineers.

Research Area(s)

  • cell imaging, Photoacoustic microscopy, Single-cell thermometry

Citation Format(s)

Single-cell photoacoustic thermometry. / Gao, Liang; Wang, Lidai; Li, Chiye et al.
In: Journal of Biomedical Optics, Vol. 18, No. 2, 26003, 02.2013.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review