TY - JOUR
T1 - Single-cell photoacoustic thermometry
AU - Gao, Liang
AU - Wang, Lidai
AU - Li, Chiye
AU - Liu, Yan
AU - Ke, Haixin
AU - Zhang, Chi
AU - Wang, Lihong V.
PY - 2013/2
Y1 - 2013/2
N2 - A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community. © Society of Photo-Optical Instrumentation Engineers.
AB - A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community. © Society of Photo-Optical Instrumentation Engineers.
KW - cell imaging
KW - Photoacoustic microscopy
KW - Single-cell thermometry
UR - http://www.scopus.com/inward/record.url?scp=84877991249&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84877991249&origin=recordpage
U2 - 10.1117/1.JBO.18.2.026003
DO - 10.1117/1.JBO.18.2.026003
M3 - RGC 21 - Publication in refereed journal
C2 - 23377004
SN - 1083-3668
VL - 18
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 2
M1 - 26003
ER -