Simulation and Sensitivity Analysis of Microtubule-Based Biomechanical Mass Detector

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Ping Xiang
  • H. P. Wang
  • L. Z. Jiang

Detail(s)

Original languageEnglish
Pages (from-to)1018-1025
Journal / PublicationJournal of Nanoscience and Nanotechnology
Volume19
Issue number2
Online published1 Feb 2019
Publication statusPublished - Feb 2019

Abstract

The microtubule is biologically the most rigid filament that is so critical to the cytoskeleton system. It is significant to study the mass sensitivity of microtubule in order to understand biophysical behaviors, such as the influence of kinesin and dynein moving along microtubules. In this research, the sensitivity of mass detector using individual microtubule is first studied. The frequency shifting of the detector due to mass loads is simulated. The influences of mass load positions and boundary conditions on the mass sensitivity are evaluated. It is predicted in this research that the mass sensitivity of a 1 mu m microtubules-based mass detector could reach 10-17 g. Results also show that the resonant frequency decreases logarithmic linearly with the increase of the attached mass regardless of the microtubule length and the position of mass load. Moreover, the sensitivity of resonant frequency shift to the microtubule length is also analyzed.

Research Area(s)

  • Microtubule, Mass Detector, Vibration Frequency, Sensitive Analysis, CAUCHY-BORN RULE, FREE-VIBRATION ANALYSIS, MESH-FREE SIMULATION, MOVING KRIGING INTERPOLATION, FREE COMPUTATIONAL FRAMEWORK, ATOMISTIC-CONTINUUM MODEL, WALLED CARBON NANOCONES, DEFORMABLE SHELL-MODEL, ORDER GRADIENT THEORY, FINITE-ELEMENT-METHOD