Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

16 Scopus Citations
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Author(s)

  • Bill WP Yip
  • Helen OL Mok
  • Y Taniguchi
  • Wei GE

Detail(s)

Original languageEnglish
Pages (from-to)701–709
Journal / PublicationMarine Pollution Bulletin
Volume124
Issue number2
Online published24 Jan 2017
Publication statusPublished - 30 Nov 2017

Abstract

Marine medaka Oryzias melastigma at 4months (young), 8months (middle-aged) and 12months old (senior) were employed to determine age-associated change of sex ratios, sex hormones, telomere length (TL), telomerase activity (TA), telomerase transcription (omTERT) and oxidative damage in the liver. Overall, O. melastigma exhibited gradual senescence, sex differences in longevity (F>M), TL (F>M) and oxidative damage (F<M) during aging. In females, the plasma E2 level was positively correlated with TL (TRF>5kb), TA and omTERT expression (p≤0.01), and negatively correlated with liver DNA oxidation (p≤0.05). The results suggest high levels of E2 in female O. melastigma may retard TL shortening by enhancing TA via TERT transcription and/or reducing oxidative DNA damage. The findings support TL shortening as a biomarker of aging and further development of accelerated TL shortening, abnormal suppression of TA and excessive oxidative DNA damage as early molecular endpoints, indicative of advanced/premature aging in marine medaka/fish.

Research Area(s)

  • Sex hormones, Telomerase and telomere, TERT, 8-OHdG, Protein carbonyl, Biomarker of aging, Longevity gender gap, Post-menopausal decline of E2

Citation Format(s)

Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging. / Yip, Bill WP; Mok, Helen OL; Peterson, Drew R et al.

In: Marine Pollution Bulletin, Vol. 124, No. 2, 30.11.2017, p. 701–709.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review