Sensitive imaging schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3T

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - May 2021

Conference

Title2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting
LocationOnline
Period15 - 20 May 2021

Abstract

We developed a high-sensitivity dynamic glucose enhanced (DGE) MRI acquisition and post-processing scheme for sensitive monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at 3T. By investigating Carr-Purcell-Meiboom-Gill sequence (CPMG), on-resonance variable delay multi-pulse (onVDMP) and on-resonance spin-locking (onSL), a high-sensitivity DGE MRI scheme composed of CPMG method for monitoring parenchyma and onVDMP method for monitoring CSF was proposed. We incorporated the multilinear singular value decomposition (MLSVD) based denoising method in post-processing, which enables the detection of DGE signals from the brain parenchyma and CSF at low concentration of D-glucose (12.5% w/w) injection.

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

Sensitive imaging schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3T. / Huang, Jianpan; Lai, Joseph H. C.; Han, Xiongqi; Chen, Zilin; Liu, Yang; Xiao, Peng; Chen, Lin; Xu, Jiadi; Chan, Kannie W. Y.

2021. Paper presented at 2021 International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting, .

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (no ISBN/ISSN)peer-review