Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

View graph of relations

Author(s)

  • Xingan Cheng
  • Huiqing He
  • Fangyun Dong
  • Hanhui Zhang
  • Jingmin Ye
  • Chuncan Tan
  • Yuehua Wu
  • Xiaojing Lv
  • Xuhong Jiang
  • Xiangjing Qin

Detail(s)

Original languageEnglish
Pages (from-to)2711-2719
Journal / PublicationPest Management Science
Volume76
Issue number8
Online published12 Mar 2020
Publication statusPublished - Aug 2020

Abstract

BACKGROUND: Matrine is an important traditional plant-derived insecticide with broad-spectrum activity. However, due to its moderate activity, matrine is mainly applied in combination with other pesticides. In order to discover new potential natural-product-based crop protection agents, a series of matrine derivatives characterized by cyclohexylamine group were synthesized to screen their insecticidal activity against seven typically agricultural pests. 

RESULTS: The structural configurations of compounds were characterized by IR, 1H NMR, 13C NMR, MS and XRD, with the pure yields of 42%, 65% and 71%, respectively. Although all compounds showed poor insecticidal activity against five lepidoptera pests, the compounds 2 and 4 displayed remarkable insecticidal activities against Lipaphis erysimi and Mulberry Root-Knot Nematode with a concentration-dependent manner within 0.5~1.5 mg/ mL. Compared with matrine (60%), compounds 2 and 4 exhibited potent insecticidal activities against L. erysimi, with a corrected mortality of 83.3% and 89.7%, respectively. They also showed excellent control effects on Mulberry Root-Knot Nematode, with corrected mortality as high as 88% and 80%, respectively. 

CONCLUSION: All four synthesized matrine derivatives showed poor insecticidal activity against five lepidoptera pests, but the compounds 2 and 4 exhibited much stronger insecticidal activities against L. erysimi and Mulberry Root-Knot Nematode than matrine. Combined with the structural characteristics of compounds 1~4, we conclude that 4-methylcyclohexylamine, not the carbon disulfide group or cyclohexylamine group alone, mainly contributed to the improvement of insecticidal activities of matrine derivatives against these two agricultural pests. This work provides a direction and foundation for structural optimization of the matrine pesticides in the future.

Research Area(s)

  • insecticidal activity, matrine derivative, structural characterization, structural modification

Citation Format(s)

Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents. / Cheng, Xingan; He, Huiqing; Wang, Wen-Xiong; Dong, Fangyun; Zhang, Hanhui; Ye, Jingmin; Tan, Chuncan; Wu, Yuehua; Lv, Xiaojing; Jiang, Xuhong; Qin, Xiangjing.

In: Pest Management Science, Vol. 76, No. 8, 08.2020, p. 2711-2719.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal