Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Shengliang Li
  • Fei-Fei An
  • Juan Liu
  • Shubin Jin
  • Jin-Chao Zhang
  • Paul C. Wang
  • Xiaohong Zhang
  • Xing-Jie Liang

Detail(s)

Original languageEnglish
Pages (from-to)13503-13510
Journal / PublicationNanoscale
Volume7
Issue number32
Online published7 Jul 2015
Publication statusPublished - 28 Aug 2015

Abstract

The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention. Despite the merits of these nanocarriers, further studies are needed to improve their drug loading capacities (which are typically <10%) and reduce their potential systemic toxicity. Therefore, the development of alternative self-carried nanodrug delivery strategies without using inert carriers is highly desirable. In this study, we developed a self-carried curcumin (Cur) nanodrug for highly effective cancer therapy in vitro and in vivo with real-time monitoring of drug release. With a biocompatible C18PMH-PEG functionalization, the Cur nanoparticles (NPs) showed excellent dispersibility and outstanding stability in physiological environments with drug loading capacities >78 wt%. Both confocal microscopy and flow cytometry confirmed the cellular fluorescence “OFF–ON” activation and real-time monitoring of the Cur molecule release. In vitro and in vivo experiments clearly show that the therapeutic efficacy of the PEGylated Cur NPs is considerably better than that of free Cur. This self-carried strategy with real-time monitoring of drug release may open a new way for simultaneous cancer therapy and monitoring.

Citation Format(s)

Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release. / Zhang, Jinfeng; Li, Shengliang; An, Fei-Fei; Liu, Juan; Jin, Shubin; Zhang, Jin-Chao; Wang, Paul C.; Zhang, Xiaohong; Lee, Chun-Sing; Liang, Xing-Jie.

In: Nanoscale, Vol. 7, No. 32, 28.08.2015, p. 13503-13510.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review