Self-assembled magnetic fluorescent polymeric micelles for magnetic resonance and optical imaging

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Kai Yan
  • Huan Li
  • Penghui Li
  • Haie Zhu
  • Jie Shen
  • Changfeng Yi
  • Shuilin Wu
  • Kelvin W.K. Yeung
  • Zushun Xu
  • Haibo Xu

Detail(s)

Original languageEnglish
Pages (from-to)344-355
Journal / PublicationBiomaterials
Volume35
Issue number1
Online published5 Oct 2013
Publication statusPublished - Jan 2014

Abstract

Stable and cytocompatible hybrid PEGylated micelles with multimodal imaging capabilities are described. The F3O4-encapsulated polymeric micelles composed of cores containing magnetic nanoparticles and polyethylene glycol (PEG) shells are synthesized by self-assembly of amphiphilic poly(HFMA-co-VBK)-g-PEG copolymers and oleic acid stabilized Fe3O4 nanoparticles. The Fe3O4 magnetic nanoparticles in the core produce T2-weighted MR imaging functionalities, whereas the small fluorescent monomer carbazole in the polymer shell introduces good fluorescent properties. The multifunctional micelles exhibit excellent paramagnetic properties with the maximum saturation magnetization of 9.61emu/g and transverse relaxivity rate of 157.44mm-1S-1. Invivo magnetic resonance imaging (MRI) studies reveal enhanced contrast between the liver and spleen. Fluorescence spectra show characteristic emission peaks from carbazole at 350nm and 365nm and vivid blue fluorescence can be observed by 2-photon confocal scanning laser microscopy (CLSM). Invivo optical imaging demonstrates the unique fluorescent characteristics of the Fe3O4-encapsulated polymeric micelles in the liver and spleen and the excellent multifunctional properties suggest potential clinical use as nanocarriers in magnetic resonance imaging and optical imaging. © 2013 Elsevier Ltd.

Research Area(s)

  • Amphiphilic copolymer, Magnetic nanoparticles, Magnetic resonance imaging, Optical imaging, Self-assembly

Citation Format(s)

Self-assembled magnetic fluorescent polymeric micelles for magnetic resonance and optical imaging. / Yan, Kai; Li, Huan; Li, Penghui; Zhu, Haie; Shen, Jie; Yi, Changfeng; Wu, Shuilin; Yeung, Kelvin W.K.; Xu, Zushun; Xu, Haibo; Chu, Paul K.

In: Biomaterials, Vol. 35, No. 1, 01.2014, p. 344-355.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review