TY - JOUR
T1 - Self-assembly of three-dimensional DNA nanostructures and potential biological applications
AU - Lo, Pik Kwan
AU - Metera, Kimberly L.
AU - Sleiman, Hanadi F.
PY - 2010/10
Y1 - 2010/10
N2 - A current challenge in nanoscience is to achieve controlled organization in three-dimensions, to provide tools for biophysics, molecular sensors, enzymatic cascades, drug delivery, tissue engineering, and device fabrication. DNA displays some of the most predictable and programmable interactions of any molecule, natural or synthetic. As a result, 3D-DNA nanostructures have emerged as promising tools for biology and materials science. In this review, strategies for 3D-DNA assembly are discussed. DNA cages, nanotubes, dendritic networks, and crystals are formed, with deliberate variation of their size, shape, persistence length, and porosities. They can exhibit dynamic character, allowing their selective switching with external stimuli. They can encapsulate and position materials into arbitrarily designed patterns, and show promise for numerous biological and materials applications. © 2010 Elsevier Ltd.
AB - A current challenge in nanoscience is to achieve controlled organization in three-dimensions, to provide tools for biophysics, molecular sensors, enzymatic cascades, drug delivery, tissue engineering, and device fabrication. DNA displays some of the most predictable and programmable interactions of any molecule, natural or synthetic. As a result, 3D-DNA nanostructures have emerged as promising tools for biology and materials science. In this review, strategies for 3D-DNA assembly are discussed. DNA cages, nanotubes, dendritic networks, and crystals are formed, with deliberate variation of their size, shape, persistence length, and porosities. They can exhibit dynamic character, allowing their selective switching with external stimuli. They can encapsulate and position materials into arbitrarily designed patterns, and show promise for numerous biological and materials applications. © 2010 Elsevier Ltd.
UR - http://www.scopus.com/inward/record.url?scp=77957751387&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-77957751387&origin=recordpage
U2 - 10.1016/j.cbpa.2010.08.002
DO - 10.1016/j.cbpa.2010.08.002
M3 - RGC 62 - Review of books or of software (or similar publications/items)
C2 - 20869905
SN - 1367-5931
VL - 14
SP - 597
EP - 607
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 5
ER -