Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jun Zhang
  • Qian-Xing Zhuang
  • Bin Li
  • Guan-Yi Wu
  • Jing-Ning Zhu
  • Jian-Jun Wang

Detail(s)

Original languageEnglish
Pages (from-to)1386-1401
Journal / PublicationMolecular Neurobiology
Volume53
Issue number2
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Abstract

Insights into function of central histaminergic system, a general modulator originating from the hypothalamus for whole brain activity, in motor control are critical for understanding the mechanism underlying somatic-nonsomatic integration. Here, we show a novel selective role of histamine in the cerebellar nuclei, the final integrative center and output of the cerebellum. Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors, which are exclusively expressed on glutamatergic and glycinergic projection neurons. Furthermore, blockage of HCN channels to block endogenous histaminergic afferent inputs in the cerebellar nuclei significantly attenuates motor balance and coordination. Therefore, through directly and quickly modulation on projection neurons but not interneurons in the cerebellar nuclei, central histaminergic system may act as a critical biasing force to not only promptly regulate ongoing movement but also realize a rapid integration of somatic and nonsomatic response. © 2015, Springer Science+Business Media New York.

Research Area(s)

  • Cerebellar nuclei, HCN channel, Histamine, Histamine H2 receptor, Motor control, Projection neurons

Bibliographic Note

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Citation Format(s)

Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels. / Zhang, Jun; Zhuang, Qian-Xing; Li, Bin et al.
In: Molecular Neurobiology, Vol. 53, No. 2, 01.03.2016, p. 1386-1401.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review