Secondary osteons scale allometrically in mammalian humerus and femur

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

12 Scopus Citations
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Author(s)

  • A. A. Felder
  • C. Phillips
  • H. Cornish
  • M. Cooke
  • J. R. Hutchinson

Detail(s)

Original languageEnglish
Article number170431
Journal / PublicationRoyal Society Open Science
Volume4
Issue number11
Online published8 Nov 2017
Publication statusPublished - Nov 2017
Externally publishedYes

Link(s)

Abstract

Intra-cortical bone remodelling is a cell-driven process that replaces existing bone tissue with new bone tissue in the bone cortex, leaving behind histological features called secondary osteons. While the scaling of bone dimensions on a macroscopic scale is well known, less is known about how the spatial dimensions of secondary osteons vary in relation to the adult body size of the species. We measured the cross-sectional area of individual intact secondary osteons and their central Haversian canals in transverse sections from 40 stylopodal bones of 39 mammalian species (body mass 0.3–21 000 kg). Scaling analysis of our data shows that mean osteonal resorption area (negative allometry, exponent 0.23, R2 0.54, < 0.005) and Haversian canal area (negative allometry, exponent 0.31, R2 0.45, p < 0.005) are significantly related to body mass, independent of phylogeny. This study is the most comprehensive of its kind to date, and allows us to describe overall trends in the scaling behaviour of secondary osteon dimensions, supporting the inference that the osteonal resorption area may be limited by the need to avoid fracture in smaller mammalian species, but the need to maintain osteocyte viability in larger mammalian species.

Research Area(s)

  • Adult body mass, Histomorphometry, Intra-cortical bone remodelling, Phylogenetic correction, Secondary osteons

Citation Format(s)

Secondary osteons scale allometrically in mammalian humerus and femur. / Felder, A. A.; Phillips, C.; Cornish, H.; Cooke, M.; Hutchinson, J. R.; Doube, M.

In: Royal Society Open Science, Vol. 4, No. 11, 170431, 11.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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