Second Near-Infrared (NIR-II) Window for Imaging-Navigated Modulation of Brain Structure and Function

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article number2206044
Journal / PublicationSmall
Volume19
Issue number14
Online published20 Jan 2023
Publication statusPublished - 5 Apr 2023

Abstract

For a long time, optical imaging of the deep brain with high resolution has been a challenge. Recently, with the advance in second near-infrared (NIR-II) bioimaging techniques and imaging contrast agents, NIR-II window bioimaging has attracted great attention to monitoring deeper biological or pathophysiological processes with high signal-to-noise ratio (SNR) and spatiotemporal resolution. Assisted with NIR-II bioimaging, the modulation of structure and function of brain is promising to be noninvasive and more precise. Herein, in this review, first the advantage of NIR-II light in brain imaging from the interaction between NIR-II and tissue is elaborated. Then, several specific NIR-II bioimaging technologies are introduced, including NIR-II fluorescence imaging, multiphoton fluorescence imaging, and photoacoustic imaging. Furthermore, the corresponding contrast agents are summarized. Next, the application of various NIR-II bioimaging technologies in visualizing the characteristics of cerebrovascular network and monitoring the changes of the pathology signals will be presented. After that, the modulation of brain structure and function based on NIR-II bioimaging will be discussed, including treatment of glioblastoma, guidance of cell transplantation, and neuromodulation. In the end, future perspectives that would help improve the clinical translation of NIR-II light are proposed. © 2023 Wiley-VCH GmbH

Research Area(s)

  • brain, imaging modality, imaging-navigated modulation, nanoprobes, second near-infrared window, 2-PHOTON EXCITATION MICROSCOPY, AG2S QUANTUM DOTS, IN-VIVO, CARBON NANOTUBES, FLUORESCENT PROTEINS, DEEP-TISSUE, PHOTOACOUSTIC TOMOGRAPHY, POLYMER NANOPARTICLES, 3-PHOTON MICROSCOPY, OPTICAL-PROPERTIES