Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yanan Huang
  • Lin Ding
  • Chenchen Li
  • Min Wu
  • Mimi Wang
  • Chenjie Yao
  • Xuelian Yin
  • Junfeng Zhang
  • Jinliang Liu
  • Minghong Wu
  • Yanli Wang

Detail(s)

Original languageEnglish
Article number1900214
Journal / PublicationParticle and Particle Systems Characterization
Volume36
Issue number10
Online published1 Aug 2019
Publication statusPublished - Oct 2019
Externally publishedYes

Abstract

When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn2+) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn2+ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO2 NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn2+ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Research Area(s)

  • combined toxicity, toxicity mechanism, zinc oxide nanoparticles

Citation Format(s)

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System. / Huang, Yanan; Ding, Lin; Li, Chenchen et al.
In: Particle and Particle Systems Characterization, Vol. 36, No. 10, 1900214, 10.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review