Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds : insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Lai-Hon Chung
  • Sheung-Ying Tse
  • Siu-Chung Chan
  • Man-Kit Tse
  • Shek-Man Yiu

Detail(s)

Original languageEnglish
Pages (from-to)12838-12842
Journal / PublicationDalton Transactions
Volume47
Issue number37
Online published5 Jul 2018
Publication statusPublished - 7 Oct 2018

Abstract

The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

Citation Format(s)

Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds : insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. / Chung, Lai-Hon; Ng, Sze-Wing; Yeung, Chi-Fung; Shek, Hau-Lam; Tse, Sheung-Ying; Lo, Hoi-Shing; Chan, Siu-Chung; Tse, Man-Kit; Yiu, Shek-Man; Wong, Chun-Yuen.

In: Dalton Transactions, Vol. 47, No. 37, 07.10.2018, p. 12838-12842.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal