TY - JOUR
T1 - Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy
AU - Chen, Rui
AU - Zhang, Jinfeng
AU - Chelora, Jipsa
AU - Xiong, Yuan
AU - Kershaw, Stephen V.
AU - Li, King Fai
AU - Lo, Pik-Kwan
AU - Cheah, Kok Wai
AU - Rogach, Andrey L.
AU - Zapien, Juan Antonio
AU - Lee, Chun-Sing
PY - 2017/2/22
Y1 - 2017/2/22
N2 - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)3 2+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)3 2+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)3 2+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)3 2+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)3 2+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.
AB - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)3 2+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)3 2+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)3 2+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)3 2+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)3 2+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.
KW - metal-organic frameworks
KW - nanoscale metal-organic frameworks
KW - photodynamic therapy
KW - theranostics
KW - two-photon excited fluorescence
UR - http://www.scopus.com/inward/record.url?scp=85013395217&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85013395217&origin=recordpage
U2 - 10.1021/acsami.6b12469
DO - 10.1021/acsami.6b12469
M3 - RGC 21 - Publication in refereed journal
SN - 1944-8244
VL - 9
SP - 5699
EP - 5708
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 7
ER -
