Ruthenaelectro-Catalyzed Domino Three-Component Alkyne Annulation for Expedient Isoquinoline Assembly

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)4619-4624
Journal / PublicationAngewandte Chemie - International Edition
Volume60
Issue number9
Online published3 Dec 2020
Publication statusPublished - 23 Feb 2021
Externally publishedYes

Abstract

The electrochemical three-component assembly of isoquinolines has been accomplished by ruthenaelectro-catalyzed C−H/N−H functionalization. The robustness of the electrocatalysis was reflected by an ample substrate scope, an efficient electrooxidation, and an operationally friendly procedure. The isolation of key intermediates and detailed mechanistic studies, including unprecedented cyclovoltammetric analysis of a seven-membered ruthenacycle, provided support for an unusual ruthenium(II/III/I) regime. © 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

Research Area(s)

  • annulation, C−H activation, domino reactions, electrocatalysis, ruthenium

Citation Format(s)

Ruthenaelectro-Catalyzed Domino Three-Component Alkyne Annulation for Expedient Isoquinoline Assembly. / Tan, Xuefeng; Hou, Xiaoyan; Rogge, Torben et al.
In: Angewandte Chemie - International Edition, Vol. 60, No. 9, 23.02.2021, p. 4619-4624.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review