Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

17 Scopus Citations
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Author(s)

  • Shengxia Yin
  • Jingjing Yu
  • Bian Hu
  • Xia Liu
  • Xianzhi Gao
  • Wei Li
  • Lina Zhou
  • Jianli Wang
  • Di Wang
  • Linrong Lu
  • Lie Wang

Detail(s)

Original languageEnglish
Article number2101
Journal / PublicationFrontiers in Immunology
Volume9
Online published12 Sept 2018
Publication statusPublished - Sept 2018
Externally publishedYes

Link(s)

Abstract

Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the mechanism by which they protect against intracellular bacterial infection is not completely understood. In this report, using S. typhimurium and L. monocytogenes, we found that the levels of group 1 ILCs and NCR+ ILC3s were increased upon infection and that these increases were associated with Runt-related transcription factor 3 (Runx3) expression. Runx3 fl/fl PLZF-cre mice were much more sensitive to infection with the intracellular bacterial pathogens S. typhimurium and L. monocytogenes partially due to abnormal Group 1 ILC and NCR+ILC3 function. We also found that Runx3 directly binds to the Il12Rβ2 promoter and intron 8 to accelerate the expression of Il12Rβ2 and modulates IFNγ secretion triggered by the IL12/ STAT4 axis. Therefore, we demonstrate that Runx3 influences group 1 ILC- and NCR+ILC3-mediated immune protection against intracellular bacterial infections of both the gut and liver.

Research Area(s)

  • Animals, Core Binding Factor Alpha 3 Subunit/genetics, Immunity, Innate, Interleukin-12/genetics, Listeria monocytogenes/immunology, Listeriosis/genetics, Lymphocytes/immunology, Mice, Mice, Transgenic, Salmonella Infections/genetics, Salmonella typhimurium/immunology, Signal Transduction/genetics

Citation Format(s)

Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3. / Yin, Shengxia; Yu, Jingjing; Hu, Bian et al.
In: Frontiers in Immunology, Vol. 9, 2101, 09.2018.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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