Projects per year
Abstract
Diphosphine-containing Ru(II)/Os(II)-chromene and -chromone complexes were synthesized from reactions between phenol ynone HC≡C(C═O)(o-C6H4OH) and cis-[Ru/Os(dppm)2Cl2] (dppm = 1,1-bis(diphenylphosphino)methane). The structures of these complexes in the solid state along with their pH-dependent chromene/chromone equilibrium behavior in aqueous medium were investigated. The cis-trans equilibration in solution demonstrated by chloride-ligated Ru-chromene and -chromone series represents a rare example for Ru complexes bearing dppm auxiliary ligands. More importantly, these metalated chromene and chromone complexes exhibit moderate to strong cytotoxicity against several human cancer cell lines and stronger antioxidative activities in comparison with their organic counterpart. Overall, these findings highlight the potential applications of metalated chromenes and chromones as anticancer agents and antioxidants.
| Original language | English |
|---|---|
| Pages (from-to) | 1299–1309 |
| Journal | Organometallics |
| Volume | 39 |
| Issue number | 8 |
| Online published | 13 Mar 2020 |
| DOIs | |
| Publication status | Published - 27 Apr 2020 |
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Dive into the research topics of 'Ru(II)- and Os(II)-Induced Cycloisomerization of Phenol-Tethered Alkyne for Functional Chromene and Chromone Complexes'. Together they form a unique fingerprint.Projects
- 3 Finished
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GRF: Rational Design of Photoresponsive Anti-Cancer Drug Delivery Nanoparticles
WONG, C. Y. A. (Principal Investigator / Project Coordinator) & LEUNG, D.C.-H. (Co-Investigator)
1/01/18 → 6/12/21
Project: Research
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TBRS: A Compact System for Terahertz Imaging and Spectroscopy
CHAN, C. H. (Principal Investigator / Project Coordinator), LO, K. W. K. (Co-Principal Investigator), LUK, K. M. (Co-Principal Investigator), PUN, Y. B. E. (Co-Principal Investigator), Pang, S. (Co-Principal Investigator), SHAW, J. (Co-Principal Investigator), VELLAISAMY, A. L. R. (Co-Principal Investigator), CHAN, S. C. (Co-Investigator), DECROZE, C. (Co-Investigator), HO, J. C. Y. (Co-Investigator), JARRAHI, M. (Co-Investigator), LAM, Y. W. (Co-Investigator), LEE, E.-Y. J. (Co-Investigator), LEE, N. P. Y. (Co-Investigator), LEUNG, K. W. (Co-Investigator), LIU, H. (Co-Investigator), QU, S. (Co-Investigator), RENAUD, C. (Co-Investigator), Tong, K. (Co-Investigator), WANG, C. (Co-Investigator), WONG, H. (Co-Investigator), WONG, C. Y. A. (Co-Investigator), WONG, M. H. A. (Co-Investigator) & Wong, K. K. Y. (Co-Investigator)
1/01/17 → 30/06/23
Project: Research
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GRF: Detecting Protein Tyrosine Kinase-7 Using Nanowire Biosensor
WONG, C. Y. A. (Principal Investigator / Project Coordinator), HO, J. C. Y. (Co-Investigator) & LEUNG, D.C.-H. (Co-Investigator)
1/09/16 → 24/08/20
Project: Research