Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device

Kerwin Kwek Zeming; Shashi Ranjan; Yong Zhang

doi:10.1038/ncomms2653

Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device

Kerwin Kwek Zeming
, Shashi Ranjan
, Yong Zhang

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

178 Citations (Scopus)

Abstract

Most bioparticles, such as red blood cells and bacteria, are non-spherical in shape. However, conventional microfluidic separation devices are designed for spherical particles. This poses a challenge in designing a separation device for non-spherical bioparticles, as the smallest dimension of the bioparticle has to be considered, which increases fabrication challenges and decreases the throughput. If current methods do not take into account the shape of non-spherical bioparticles, the separation will be inefficient. Here, to address this challenge, we present a novel technique for the separation of red blood cells as a non-spherical bioparticle, using a new I-shaped pillar arrays design. It takes the shape into account and induces rotational movements, allowing us to leverage on the largest dimension, which increases its separation size. This technique has been used for 100% separation of red blood cells from blood samples in a focused stream, outperforming the conventional pillar array designs. © 2013 Macmillan Publishers Limited. All rights reserved.

Original language	English
Article number	1625
Journal	Nature Communications
Volume	4
DOIs	https://doi.org/10.1038/ncomms2653
Publication status	Published - 2013
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

We acknowledge the National University of Singapore (NUS) and A*STAR SERC (Project number R-397-000-122-305) for the funding support, as well as the Institute of Materials Research and Engineering (IMRE) for providing the microfabrication facilities.

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title = "Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device",

abstract = "Most bioparticles, such as red blood cells and bacteria, are non-spherical in shape. However, conventional microfluidic separation devices are designed for spherical particles. This poses a challenge in designing a separation device for non-spherical bioparticles, as the smallest dimension of the bioparticle has to be considered, which increases fabrication challenges and decreases the throughput. If current methods do not take into account the shape of non-spherical bioparticles, the separation will be inefficient. Here, to address this challenge, we present a novel technique for the separation of red blood cells as a non-spherical bioparticle, using a new I-shaped pillar arrays design. It takes the shape into account and induces rotational movements, allowing us to leverage on the largest dimension, which increases its separation size. This technique has been used for 100\% separation of red blood cells from blood samples in a focused stream, outperforming the conventional pillar array designs. {\textcopyright} 2013 Macmillan Publishers Limited. All rights reserved.",

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AU - Zeming, Kerwin Kwek

AU - Ranjan, Shashi

AU - Zhang, Yong

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2013

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N2 - Most bioparticles, such as red blood cells and bacteria, are non-spherical in shape. However, conventional microfluidic separation devices are designed for spherical particles. This poses a challenge in designing a separation device for non-spherical bioparticles, as the smallest dimension of the bioparticle has to be considered, which increases fabrication challenges and decreases the throughput. If current methods do not take into account the shape of non-spherical bioparticles, the separation will be inefficient. Here, to address this challenge, we present a novel technique for the separation of red blood cells as a non-spherical bioparticle, using a new I-shaped pillar arrays design. It takes the shape into account and induces rotational movements, allowing us to leverage on the largest dimension, which increases its separation size. This technique has been used for 100% separation of red blood cells from blood samples in a focused stream, outperforming the conventional pillar array designs. © 2013 Macmillan Publishers Limited. All rights reserved.

AB - Most bioparticles, such as red blood cells and bacteria, are non-spherical in shape. However, conventional microfluidic separation devices are designed for spherical particles. This poses a challenge in designing a separation device for non-spherical bioparticles, as the smallest dimension of the bioparticle has to be considered, which increases fabrication challenges and decreases the throughput. If current methods do not take into account the shape of non-spherical bioparticles, the separation will be inefficient. Here, to address this challenge, we present a novel technique for the separation of red blood cells as a non-spherical bioparticle, using a new I-shaped pillar arrays design. It takes the shape into account and induces rotational movements, allowing us to leverage on the largest dimension, which increases its separation size. This technique has been used for 100% separation of red blood cells from blood samples in a focused stream, outperforming the conventional pillar array designs. © 2013 Macmillan Publishers Limited. All rights reserved.

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U2 - 10.1038/ncomms2653

DO - 10.1038/ncomms2653

M3 - RGC 21 - Publication in refereed journal

C2 - 23535646

SN - 2041-1723

VL - 4

JO - Nature Communications

JF - Nature Communications

M1 - 1625

ER -

Rotational separation of non-spherical bioparticles using I-shaped pillar arrays in a microfluidic device

Abstract

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