Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Beike Wang
  • Jia-Hong Wang
  • Qian Liu
  • Hao Huang
  • Ming Chen
  • Kaiyang Li
  • Chengzhang Li
  • Xue-Feng Yu

Detail(s)

Original languageEnglish
Pages (from-to)1954-1966
Journal / PublicationBiomaterials
Volume35
Issue number6
Online published9 Dec 2013
Publication statusPublished - Feb 2014

Abstract

Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. © 2013 Elsevier Ltd.

Research Area(s)

  • Gold nanorods, Oral cancer, Photodynamic therapy, Photothermal therapy, Rose bengal

Citation Format(s)

Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies. / Wang, Beike; Wang, Jia-Hong; Liu, Qian; Huang, Hao; Chen, Ming; Li, Kaiyang; Li, Chengzhang; Yu, Xue-Feng; Chu, Paul. K.

In: Biomaterials, Vol. 35, No. 6, 02.2014, p. 1954-1966.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review