Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

Beike Wang; Jia-Hong Wang; Qian Liu; Hao Huang; Ming Chen; Kaiyang Li; Chengzhang Li; Xue-Feng Yu; Paul. K. Chu

doi:10.1016/j.biomaterials.2013.11.066

Author(s)

Beike Wang
Jia-Hong Wang
Qian Liu
Hao Huang
Ming Chen
Kaiyang Li
Chengzhang Li
Xue-Feng Yu

Detail(s)

Original language	English
Pages (from-to)	1954-1966
Journal / Publication	Biomaterials
Volume	35
Issue number	6
Online published	9 Dec 2013
Publication status	Published - Feb 2014

Link(s)

DOI	DOI https://doi.org/10.1016/j.biomaterials.2013.11.066 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84890197157&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(5fdbee23-5633-4007-b493-e8468acdad11).html

Abstract

Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. © 2013 Elsevier Ltd.

Research Area(s)

Gold nanorods, Oral cancer, Photodynamic therapy, Photothermal therapy, Rose bengal

Citation Format(s)

[ RIS ] [ BibTeX ]

Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies. / Wang, Beike; Wang, Jia-Hong; Liu, Qian et al.

In: Biomaterials, Vol. 35, No. 6, 02.2014, p. 1954-1966.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Wang, B, Wang, J-H, Liu, Q, Huang, H, Chen, M, Li, K, Li, C, Yu, X-F & Chu, PK 2014, 'Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies', Biomaterials, vol. 35, no. 6, pp. 1954-1966. https://doi.org/10.1016/j.biomaterials.2013.11.066

Wang, B., Wang, J-H., Liu, Q., Huang, H., Chen, M., Li, K., Li, C., Yu, X-F., & Chu, P. K. (2014). Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies. Biomaterials, 35(6), 1954-1966. https://doi.org/10.1016/j.biomaterials.2013.11.066

Wang B, Wang J-H, Liu Q, Huang H, Chen M, Li K et al. Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies. Biomaterials. 2014 Feb;35(6):1954-1966. Epub 2013 Dec 9. doi: 10.1016/j.biomaterials.2013.11.066

Wang, Beike ; Wang, Jia-Hong ; Liu, Qian et al. / Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies. In: Biomaterials. 2014 ; Vol. 35, No. 6. pp. 1954-1966.