Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

Beike Wang; Jia-Hong Wang; Qian Liu; Hao Huang; Ming Chen; Kaiyang Li; Chengzhang Li; Xue-Feng Yu; Paul. K. Chu

doi:10.1016/j.biomaterials.2013.11.066

Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

Beike Wang, Jia-Hong Wang, Qian Liu, Hao Huang, Ming Chen, Kaiyang Li, Chengzhang Li^*, Xue-Feng Yu^*, Paul. K. Chu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

311 Citations (Scopus)

Abstract

Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. © 2013 Elsevier Ltd.

Original language	English
Pages (from-to)	1954-1966
Journal	Biomaterials
Volume	35
Issue number	6
Online published	9 Dec 2013
DOIs	https://doi.org/10.1016/j.biomaterials.2013.11.066
Publication status	Published - Feb 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Gold nanorods
Oral cancer
Photodynamic therapy
Photothermal therapy
Rose bengal

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10.1016/j.biomaterials.2013.11.066

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title = "Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies",

abstract = "Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. {\textcopyright} 2013 Elsevier Ltd.",

keywords = "Gold nanorods, Oral cancer, Photodynamic therapy, Photothermal therapy, Rose bengal",

author = "Beike Wang and Jia-Hong Wang and Qian Liu and Hao Huang and Ming Chen and Kaiyang Li and Chengzhang Li and Xue-Feng Yu and Chu, {Paul. K.}",

year = "2014",

month = feb,

doi = "10.1016/j.biomaterials.2013.11.066",

language = "English",

volume = "35",

pages = "1954--1966",

journal = "Biomaterials",

issn = "0142-9612",

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TY - JOUR

T1 - Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

AU - Wang, Beike

AU - Wang, Jia-Hong

AU - Liu, Qian

AU - Huang, Hao

AU - Chen, Ming

AU - Li, Kaiyang

AU - Li, Chengzhang

AU - Yu, Xue-Feng

AU - Chu, Paul. K.

PY - 2014/2

Y1 - 2014/2

N2 - Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. © 2013 Elsevier Ltd.

AB - Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532nm green light and high photothermal efficiency under 810nm near-infrared (NIR) irradiation. Invitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. Invivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. © 2013 Elsevier Ltd.

KW - Gold nanorods

KW - Oral cancer

KW - Photodynamic therapy

KW - Photothermal therapy

KW - Rose bengal

UR - http://www.scopus.com/inward/record.url?scp=84890197157&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84890197157&origin=recordpage

U2 - 10.1016/j.biomaterials.2013.11.066

DO - 10.1016/j.biomaterials.2013.11.066

M3 - RGC 21 - Publication in refereed journal

C2 - 24331707

SN - 0142-9612

VL - 35

SP - 1954

EP - 1966

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Rose-bengal-conjugated gold nanorods for invivo photodynamic and photothermal oral cancer therapies

Abstract

UN SDGs

Research Keywords

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