Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids

Huiyong Yin; Yunhua Zhou; Mingjiang Zhu; Sarina Hou; Zi Li; Huiqin Zhong; Jianhong Lu; Tao Meng; Junhong Wang; Lin Xia; Yue Xu; Yuncheng Wu

doi:10.1016/j.mito.2012.10.003

Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids

Huiyong Yin, Yunhua Zhou, Mingjiang Zhu, Sarina Hou, Zi Li, Huiqin Zhong, Jianhong Lu, Tao Meng, Junhong Wang, Lin Xia, Yue Xu, Yuncheng Wu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

48 Citations (Scopus)

Abstract

Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes. Most eicosanoids act primarily on their respective cell surface G-protein coupled receptors to elicit downstream signaling in an autocrine and paracrine fashion. Emerging evidence indicates that these hormones are also critical in apoptosis in a cell/tissue specific manner. In this review, we summarize the formation of eicosanoids and their roles as mediators in apoptosis, specifically on the roles of mitochondria in mediating these events and the signaling pathways involved. The biological relevance of eicosanoid-mediated apoptosis is also discussed. © 2012 Elsevier B.V. and Mitochondria Research Society.

Original language	English
Pages (from-to)	209-224
Journal	Mitochondrion
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.mito.2012.10.003
Publication status	Published - May 2013
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Apoptosis
Mitochondria
Prostaglandins
Reactive oxygen species

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abstract = "Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes. Most eicosanoids act primarily on their respective cell surface G-protein coupled receptors to elicit downstream signaling in an autocrine and paracrine fashion. Emerging evidence indicates that these hormones are also critical in apoptosis in a cell/tissue specific manner. In this review, we summarize the formation of eicosanoids and their roles as mediators in apoptosis, specifically on the roles of mitochondria in mediating these events and the signaling pathways involved. The biological relevance of eicosanoid-mediated apoptosis is also discussed. {\textcopyright} 2012 Elsevier B.V. and Mitochondria Research Society.",

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note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

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T1 - Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids

AU - Yin, Huiyong

AU - Zhou, Yunhua

AU - Zhu, Mingjiang

AU - Hou, Sarina

AU - Li, Zi

AU - Zhong, Huiqin

AU - Lu, Jianhong

AU - Meng, Tao

AU - Wang, Junhong

AU - Xia, Lin

AU - Xu, Yue

AU - Wu, Yuncheng

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2013/5

Y1 - 2013/5

N2 - Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes. Most eicosanoids act primarily on their respective cell surface G-protein coupled receptors to elicit downstream signaling in an autocrine and paracrine fashion. Emerging evidence indicates that these hormones are also critical in apoptosis in a cell/tissue specific manner. In this review, we summarize the formation of eicosanoids and their roles as mediators in apoptosis, specifically on the roles of mitochondria in mediating these events and the signaling pathways involved. The biological relevance of eicosanoid-mediated apoptosis is also discussed. © 2012 Elsevier B.V. and Mitochondria Research Society.

AB - Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes. Most eicosanoids act primarily on their respective cell surface G-protein coupled receptors to elicit downstream signaling in an autocrine and paracrine fashion. Emerging evidence indicates that these hormones are also critical in apoptosis in a cell/tissue specific manner. In this review, we summarize the formation of eicosanoids and their roles as mediators in apoptosis, specifically on the roles of mitochondria in mediating these events and the signaling pathways involved. The biological relevance of eicosanoid-mediated apoptosis is also discussed. © 2012 Elsevier B.V. and Mitochondria Research Society.

KW - Apoptosis

KW - Mitochondria

KW - Prostaglandins

KW - Reactive oxygen species

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U2 - 10.1016/j.mito.2012.10.003

DO - 10.1016/j.mito.2012.10.003

M3 - RGC 21 - Publication in refereed journal

C2 - 23063711

SN - 1567-7249

VL - 13

SP - 209

EP - 224

JO - Mitochondrion

JF - Mitochondrion

IS - 3

ER -

Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids

Abstract

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