Role of intravital imaging in nanomedicine-assisted anti-cancer therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Lisen Lu
  • Yajie Sun
  • Chao Wan
  • Yan Hu
  • Jonathan F Lovell
  • Kunyu Yang
  • Honglin Jin

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)153-161
Journal / PublicationCurrent Opinion in Biotechnology
Volume69
Online published18 Jan 2021
Publication statusPublished - Jun 2021

Abstract

Although nanomedicines have provided promising anti-tumor effects in cancer animal models, their clinical success remains limited. One of the most significant barriers in the clinical translation of nanomedicines is that they consist of multiple components, each of which may have different toxicities and therapeutic effects. Intravital imaging provides high spatial and temporal resolution for visualizing nanomedicine-mediated interactions between immune cells and tumor cells in real-time. Intravital imaging can facilitate the in vivo evaluation of the properties and effects of nanomedicines, such as their ability to cross the tumor vasculature, specifically eliminate the cancer cells, and modulate the immune cells found in the tumor microenvironment (TME). Thus, intravital imaging can provide direct evidence of nanomedicine's intravital behavior to better understand mechanism and accelerate clinical translation. In this review, we summarize several applications and latest advances in intravital imaging in nanomedicine-assisted anti-cancer therapy and discuss future perspectives in the field.

Citation Format(s)

Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. / Lu, Lisen; Sun, Yajie; Wan, Chao; Hu, Yan; Lo, Pui-Chi; Lovell, Jonathan F; Yang, Kunyu; Jin, Honglin.

In: Current Opinion in Biotechnology, Vol. 69, 06.2021, p. 153-161.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review