rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment

Ho Chi Joseph Lai; Tian Yang; Jianpan Huang; Yang LIU; Youngjin Lee; Wai Yan Kannie Chan

doi:10.58530/2022/3858

rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment

Ho Chi Joseph Lai, Tian Yang, Jianpan Huang, Yang LIU, Youngjin Lee, Wai Yan Kannie Chan^*

^*Corresponding author for this work

Research output: Conference Papers › Abstract › peer-review

Abstract

We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally. As demonstrated by our published work, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.

Original language	English
DOIs	https://doi.org/10.58530/2022/3858
Publication status	Published - May 2022
Event	2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting - Hybrid, London, United Kingdom Duration: 7 May 2022 → 12 May 2022 https://www.ismrm.org/22m/

Conference

Conference	2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting
Place	United Kingdom
City	London
Period	7/05/22 → 12/05/22
Internet address	https://www.ismrm.org/22m/

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@conference{ac06811dc184499398396ee79e2f8cbd,

title = "rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment",

abstract = "We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally. As demonstrated by our published work, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.",

author = "Lai, {Ho Chi Joseph} and Tian Yang and Jianpan Huang and Yang LIU and Youngjin Lee and Chan, {Wai Yan Kannie}",

year = "2022",

month = may,

doi = "10.58530/2022/3858",

language = "English",

note = "2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting ; Conference date: 07-05-2022 Through 12-05-2022",

url = "https://www.ismrm.org/22m/",

}

TY - CONF

T1 - rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment

AU - Lai, Ho Chi Joseph

AU - Yang, Tian

AU - Huang, Jianpan

AU - LIU, Yang

AU - Lee, Youngjin

AU - Chan, Wai Yan Kannie

PY - 2022/5

Y1 - 2022/5

N2 - We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally. As demonstrated by our published work, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.

AB - We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally. As demonstrated by our published work, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.

U2 - 10.58530/2022/3858

DO - 10.58530/2022/3858

M3 - Abstract

T2 - 2022 Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting

Y2 - 7 May 2022 through 12 May 2022

ER -

rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment

Abstract

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