RNA interference and antiviral therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)Editorial Preface

35 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)5169-5179
Journal / PublicationWorld Journal of Gastroenterology
Volume13
Issue number39
Publication statusPublished - 21 Oct 2007
Externally publishedYes

Abstract

RNA interference (RNAi) is an evolutionally conserved gene silencing mechanism present in a variety of eukaryotic species. RNAi uses short double-stranded RNA (dsRNA) to trigger degradation or translation repression of homologous RNA targets in a sequence-specific manner. This system can be induced effectively in vitro and in vivo by direct application of small interfering RNAs (siRNAs), or by expression of short hairpin RNA (shRNA) with non-viral and viral vectors. To date, RNAi has been extensively used as a novel and effective tool for functional genomic studies, and has displayed great potential in treating human diseases, including human genetic and acquired disorders such as cancer and viral infections. In the present review, we focus on the recent development in the use of RNAi in the prevention and treatment of viral infections. The mechanisms, strategies, hurdles and prospects of employing RNAi in the pharmaceutical industry are also discussed. © 2007 WJG. All rights reserved.

Research Area(s)

  • Antiviral therapy, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Micro RNA, RNA interference, SARS-coronavirus, Short hairpin RNA, Viral infection

Citation Format(s)

RNA interference and antiviral therapy. / Ma, Yan; Chan, Chu-Yan; He, Ming-Liang.

In: World Journal of Gastroenterology, Vol. 13, No. 39, 21.10.2007, p. 5169-5179.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)Editorial Preface