RNA G-quadruplexes (rG4s) : Genomics and biological functions

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)5426-5450
Journal / PublicationNucleic Acids Research
Volume49
Issue number10
Online published27 Mar 2021
Publication statusPublished - 4 Jun 2021

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Abstract

G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that have been first observed decades ago. Over the years, these four-stranded structural motifs have been demonstrated to have significant regulatory roles in diverse biological processes, but challenges remain in detecting them globally and reliably. Compared to DNA G4s (dG4s), the study of RNA G4s (rG4s) has received less attention until recently. In this review, we will summarize the innovative high-throughput methods recently developed to detect rG4s on a transcriptome-wide scale, highlight the many novel and important functions of rG4 being discovered in vivo across the tree of life, and discuss the key biological questions to be addressed in the near future.

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Citation Format(s)

RNA G-quadruplexes (rG4s) : Genomics and biological functions. / Lyu, Kaixin; Chow, Eugene Yui-Ching; Mou, Xi; Chan, Ting-Fung; Kwok, Chun Kit.

In: Nucleic Acids Research, Vol. 49, No. 10, 04.06.2021, p. 5426-5450.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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