Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Yau-Lam Alex Chau; Ji Won Yoo; Jiandong Zhou; Cosmos LiutaoGuo; Wing Tak Wong; Carlin Chang; Tong Liu; Kamalan Jeevaratnam; Qingpeng Zhang; Gary Tse; Sharen Lee

doi:10.1016/j.ahr.2023.100155

Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Yau-Lam Alex Chau
, Ji Won Yoo
, Jiandong Zhou
, Cosmos LiutaoGuo
, Wing Tak Wong
, Carlin Chang
, Tong Liu
, Kamalan Jeevaratnam
, Qingpeng Zhang
, Gary Tse^*
, Sharen Lee^*

^*Corresponding author for this work

Department of Data Science

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

54 Downloads (CityUHK Scholars)

Abstract

This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia. © 2023

Original language	English
Article number	100155
Journal	Aging and Health Research
Volume	3
Issue number	3
Online published	2 Aug 2023
DOIs	https://doi.org/10.1016/j.ahr.2023.100155
Publication status	Published - Sept 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Dementia
Risk factors
Type 2 diabetes
Vascular

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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@article{76b9d591b2bd49a797a5fff312f3fffe,

title = "Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study",

abstract = "This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95\% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia. {\textcopyright} 2023",

keywords = "Dementia, Risk factors, Type 2 diabetes, Vascular",

author = "Chau, \{Yau-Lam Alex\} and Yoo, \{Ji Won\} and Jiandong Zhou and Cosmos LiutaoGuo and Wong, \{Wing Tak\} and Carlin Chang and Tong Liu and Kamalan Jeevaratnam and Qingpeng Zhang and Gary Tse and Sharen Lee",

year = "2023",

month = sep,

doi = "10.1016/j.ahr.2023.100155",

language = "English",

volume = "3",

journal = "Aging and Health Research",

issn = "2667-0321",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Risk factors of dementia in type 2 diabetes mellitus

T2 - The Hong Kong diabetes study

AU - Chau, Yau-Lam Alex

AU - Yoo, Ji Won

AU - Zhou, Jiandong

AU - LiutaoGuo, Cosmos

AU - Wong, Wing Tak

AU - Chang, Carlin

AU - Liu, Tong

AU - Jeevaratnam, Kamalan

AU - Zhang, Qingpeng

AU - Tse, Gary

AU - Lee, Sharen

PY - 2023/9

Y1 - 2023/9

N2 - This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia. © 2023

AB - This population-based cohort study investigated the risk factors of incident dementia and vascular dementia in type 2 diabetic patients (≥45 years old) attending the Hong Kong Hospital Authority between 1st January and 31st December 2009.Of the 273,876 patients included,9994 showed incident dementia (median follow-up: 4245 days). Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia. © 2023

KW - Dementia

KW - Risk factors

KW - Type 2 diabetes

KW - Vascular

UR - https://www.scopus.com/pages/publications/85174938045

UR - https://www.scopus.com/pages/publications/85174938045#tab=impact

U2 - 10.1016/j.ahr.2023.100155

DO - 10.1016/j.ahr.2023.100155

M3 - RGC 21 - Publication in refereed journal

SN - 2667-0321

VL - 3

JO - Aging and Health Research

JF - Aging and Health Research

IS - 3

M1 - 100155

ER -

Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study

Abstract

UN SDGs

Research Keywords

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