Revisiting blob theory for DNA diffusivity in slitlike confinement

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Liang Dai
  • Douglas R. Tree
  • Johan R. C. van der Maarel
  • Kevin D. Dorfman
  • Patrick S. Doyle

Detail(s)

Original languageEnglish
Article number168105
Journal / PublicationPhysical Review Letters
Volume110
Issue number16
Online published19 Apr 2013
Publication statusPublished - 19 Apr 2013
Externally publishedYes

Abstract

Blob theory has been widely applied to describe polymer conformations and dynamics in nanoconfinement. In slit confinement, blob theory predicts a scaling exponent of 2/3 for polymer diffusivity as a function of slit height, yet a large body of experimental studies using DNA produce a scaling exponent significantly less than 2/3. In this work, we develop a theory that predicts that this discrepancy occurs because the segment correlation function for a semiflexible chain such as DNA does not follow the Flory exponent for length scales smaller than the persistence length. We show that these short length scale effects contribute significantly to the scaling for the DNA diffusivity, but do not appreciably affect the scalings for static properties. Our theory is fully supported by Monte Carlo simulations, quantitative agreement with DNA experiments, and the results reconcile this outstanding problem for confined polymers. © 2013 American Physical Society.

Citation Format(s)

Revisiting blob theory for DNA diffusivity in slitlike confinement. / Dai, Liang; Tree, Douglas R.; van der Maarel, Johan R. C. et al.
In: Physical Review Letters, Vol. 110, No. 16, 168105, 19.04.2013.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review