Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

W. F. Fong; C. Wang; G. Y. Zhu; C. H. Leung; M. S. Yang; H. Y. Cheung

doi:10.1016/j.phymed.2006.03.004

Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Overview

55 Scopus Citations

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Author(s)

W. F. Fong
C. Wang
G. Y. Zhu
C. H. Leung
H. Y. Cheung

Detail(s)

Original language	English
Pages (from-to)	160-165
Journal / Publication	Phytomedicine
Volume	14
Issue number	2-3
Publication status	Published - 19 Feb 2007

Link(s)

DOI	DOI https://doi.org/10.1016/j.phymed.2006.03.004 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-33846397852&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(a2314606-402f-44e5-851d-4220818d5b23).html

Abstract

Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G₂/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved.