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Retrospective causal inference with multiple effect variables

    Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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    Abstract

    As highlighted in Dawid (2000) and Pearl & Mackenzie (2018), deducing the causes of given effects is a more challenging problem than evaluating the effects of causes in causal inference. Lu et al. (2023) proposed an approach for deducing causes of a single effect variable based on posterior causal effects. In many applications, there are multiple effect variables, and they can be used simultaneously to more accurately deduce the causes. To retrospectively deduce causes from multiple effects, we propose multivariate posterior total, intervention and direct causal effects conditional on the observed evidence. We describe the assumptions of no confounding and monotonicity, under which we prove identifiability of the multivariate posterior causal effects and provide their identification equations. The proposed approach can be applied for causal attributions, medical diagnosis, blame and responsibility in various studies with multiple effect or outcome variables. Two examples are used to illustrate the proposed approach. © The Author(s) 2023.
    Original languageEnglish
    Pages (from-to)573-589
    JournalBiometrika
    Volume111
    Issue number2
    DOIs
    Publication statusPublished - 14 Sept 2023

    Funding

    We thank the editor, an associate editor and two reviewers for their very insightful and helpful comments, which led to a significant improvement of our paper. This research was partially supported by the National Key R&D Program of China (2022YFA1008100, and 2020YFE0204200), the National Natural Science Foundation of China (12101607, 12071015), Beijing Natural Science Foundation (1232008), the National Statistical Science Research Project (2022LZ13), Hong Kong Innovation and Technology Commission with InnoHK Project CIMDA, and the Hong Kong Institute of Data Science (9360163). The public computing cloud from the Renmin University of China was used to perform the simulation and data analysis. Li and Lu contributed equally to this work.

    Research Keywords

    • Causal attribution
    • Cause of effect
    • Medical diagnosis
    • Multivariate posterior causal effect

    Publisher's Copyright Statement

    • COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is a pre-copyedited, author-produced version of an article accepted for publication in Biometrika following peer review. The version of record Wei Li, Zitong Lu, Jinzhu Jia, Min Xie, Zhi Geng, Retrospective causal inference with multiple effect variables, Biometrika, Volume 111, Issue 2, June 2024, Pages 573–589, https://doi.org/10.1093/biomet/asad056 is available online at: https://academic.oup.com/biomet/article/111/2/573/7273778.

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