Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

7 Scopus Citations
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Author(s)

  • Huating Li
  • Lei Zhang
  • Qian Wu
  • Lingling Qian
  • Yueqiong Ni
  • Petia Kovatcheva-Datchary
  • Rui Yuan
  • Shuangbo Liu
  • Li Shen
  • Mingliang Zhang
  • Bin Sheng
  • Ping Li
  • Kang Kang
  • Liang Wu
  • Qichen Fang
  • Xiaoxue Long
  • Xiaolin Wang
  • Yanli Li
  • Yaorui Ye
  • Jianping Ye
  • Yuqian Bao
  • Yueliang Zhao
  • Guowang Xu
  • Xinyu Liu
  • Gianni Panagiotou
  • Aimin Xu
  • Weiping Jia

Detail(s)

Original languageEnglish
Pages (from-to)578–597
Journal / PublicationNature Metabolism
Volume6
Issue number3
Online published26 Feb 2024
Publication statusPublished - Mar 2024

Link(s)

Abstract

Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B. adolescentis and that the gut microbiota is essential for the action of RS. © The Author(s) 2024.

Research Area(s)

Citation Format(s)

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. / Li, Huating; Zhang, Lei; Li, Jun et al.
In: Nature Metabolism, Vol. 6, No. 3, 03.2024, p. 578–597.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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