Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Huating Li; Lei Zhang; Jun Li; Qian Wu; Lingling Qian; Junsheng He; Yueqiong Ni; Petia Kovatcheva-Datchary; Rui Yuan; Shuangbo Liu; Li Shen; Mingliang Zhang; Bin Sheng; Ping Li; Kang Kang; Liang Wu; Qichen Fang; Xiaoxue Long; Xiaolin Wang; Yanli Li; Yaorui Ye; Jianping Ye; Yuqian Bao; Yueliang Zhao; Guowang Xu; Xinyu Liu; Gianni Panagiotou; Aimin Xu; Weiping Jia

doi:10.1038/s42255-024-00988-y

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Huating Li^* (Co-first Author), Lei Zhang (Co-first Author), Jun Li (Co-first Author), Qian Wu (Co-first Author), Lingling Qian, Junsheng He, Yueqiong Ni, Petia Kovatcheva-Datchary, Rui Yuan, Shuangbo Liu, Li Shen, Mingliang Zhang, Bin Sheng, Ping Li, Kang Kang, Liang Wu, Qichen Fang, Xiaoxue Long, Xiaolin Wang, Yanli LiYaorui Ye, Jianping Ye, Yuqian Bao, Yueliang Zhao, Guowang Xu, Xinyu Liu^*, Gianni Panagiotou^*, Aimin Xu^*, Weiping Jia^*

^*Corresponding author for this work

Department of Infectious Diseases and Public Health

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

166 Citations (Scopus)

208 Downloads (CityUHK Scholars)

Abstract

Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B. adolescentis and that the gut microbiota is essential for the action of RS. © The Author(s) 2024.

Original language	English
Pages (from-to)	578–597
Journal	Nature Metabolism
Volume	6
Issue number	3
Online published	26 Feb 2024
DOIs	https://doi.org/10.1038/s42255-024-00988-y
Publication status	Published - Mar 2024

Funding

We thank the medical staf and study participants who took part in the trial. The authors thank J. Wu and R. Zeng for valuable suggestions. This work was supported by the National Key Research and Development Program of China (2022YFA1004804), Shanghai Municipal Key Clinical Specialty, Shanghai Research Center for Endocrine and Metabolic Diseases (2022ZZ01002) and National Natural Science Foundation of China (NSFC) major international (regional) joint research project (81220108006) to W.J.; Excellent Young Scientists Fund of NSFC (82022012), General Fund of NSFC (82270907), Major Program of NSFC (92357305), Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212700), Hong Kong Scholars Program (XJ2013035) and Two Hundred Program from Shanghai Jiao Tong University School of Medicine to H.L.; Hong Kong Research Grant Council (AOE/M/707-18) to A.X.; Marie Sklodowska-Curie Actions and Innovative Training Networks (H2020-MSCA-ITN-2018 813781) to G.P., DFG under Germany’s Excellence Strategy (EXC 2051) project ID 390713860 to G.P. and Y.N.; Shenzhen Basic Research Program (JCYJ20190808182402941) and Guangdong Basic and Applied Research Major Program (2019B030302005) to J.L.; Key foundation of NSFC (21934006), Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB38020200) to G.X.; the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2021186) to X. Liu.; and The Hong Kong Polytechnic University (P0042740) to P.L.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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10.1038/s42255-024-00988-y

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Li, H., Zhang, L., Li, J., Wu, Q., Qian, L., He, J., Ni, Y., Kovatcheva-Datchary, P., Yuan, R., Liu, S., Shen, L., Zhang, M., Sheng, B., Li, P., Kang, K., Wu, L., Fang, Q., Long, X., Wang, X., ... Jia, W. (2024). Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nature Metabolism, 6(3), 578–597. https://doi.org/10.1038/s42255-024-00988-y

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abstract = "Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B. adolescentis and that the gut microbiota is essential for the action of RS. {\textcopyright} The Author(s) 2024.",

author = "Huating Li and Lei Zhang and Jun Li and Qian Wu and Lingling Qian and Junsheng He and Yueqiong Ni and Petia Kovatcheva-Datchary and Rui Yuan and Shuangbo Liu and Li Shen and Mingliang Zhang and Bin Sheng and Ping Li and Kang Kang and Liang Wu and Qichen Fang and Xiaoxue Long and Xiaolin Wang and Yanli Li and Yaorui Ye and Jianping Ye and Yuqian Bao and Yueliang Zhao and Guowang Xu and Xinyu Liu and Gianni Panagiotou and Aimin Xu and Weiping Jia",

year = "2024",

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Li, H, Zhang, L, Li, J, Wu, Q, Qian, L, He, J, Ni, Y, Kovatcheva-Datchary, P, Yuan, R, Liu, S, Shen, L, Zhang, M, Sheng, B, Li, P, Kang, K, Wu, L, Fang, Q, Long, X, Wang, X, Li, Y, Ye, Y, Ye, J, Bao, Y, Zhao, Y, Xu, G, Liu, X, Panagiotou, G, Xu, A & Jia, W 2024, 'Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota', Nature Metabolism, vol. 6, no. 3, pp. 578–597. https://doi.org/10.1038/s42255-024-00988-y

TY - JOUR

T1 - Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

AU - Li, Huating

AU - Zhang, Lei

AU - Li, Jun

AU - Wu, Qian

AU - Qian, Lingling

AU - He, Junsheng

AU - Ni, Yueqiong

AU - Kovatcheva-Datchary, Petia

AU - Yuan, Rui

AU - Liu, Shuangbo

AU - Shen, Li

AU - Zhang, Mingliang

AU - Sheng, Bin

AU - Li, Ping

AU - Kang, Kang

AU - Wu, Liang

AU - Fang, Qichen

AU - Long, Xiaoxue

AU - Wang, Xiaolin

AU - Li, Yanli

AU - Ye, Yaorui

AU - Ye, Jianping

AU - Bao, Yuqian

AU - Zhao, Yueliang

AU - Xu, Guowang

AU - Liu, Xinyu

AU - Panagiotou, Gianni

AU - Xu, Aimin

AU - Jia, Weiping

PY - 2024/3

Y1 - 2024/3

N2 - Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B. adolescentis and that the gut microbiota is essential for the action of RS. © The Author(s) 2024.

AB - Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B. adolescentis and that the gut microbiota is essential for the action of RS. © The Author(s) 2024.

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DO - 10.1038/s42255-024-00988-y

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C2 - 38409604

SN - 2522-5812

VL - 6

SP - 578

EP - 597

JO - Nature Metabolism

JF - Nature Metabolism

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ER -

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Abstract

Funding

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AoE(UGC)-ExtU-Lead: Institute of Metabolic Medicine

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Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Abstract

Funding

UN SDGs

Publisher's Copyright Statement

RGC Funding Information

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Permanent Link

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AoE(UGC)-ExtU-Lead: Institute of Metabolic Medicine

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